Ophthalmology

The Environment Exacerbates Dry Eye. Our Dry Eye Chamber Creates the Environment.

For clinical testing of potential dry eye treatments, you can ask patients to drive with the top down, climb mountains or take a flight for just the right environmental conditions to exacerbate the condition.

Or you can come to Cetero and let us create the environment for you. Our Dry Eye Environmental Exposure Chamber is an innovative approach that provides standardized, carefully controlled environmental conditions to significantly and reproducibly exacerbate symptoms of dry eye. It complements Cetero’s aerosolized allergen models – well established, regulatory-accepted clinical models that we have used for respiratory and immunology drug development since 2001.

Cetero’s Dry Eye Chamber provides a controlled low humidity environment (less than 10%) comparable to dry indoor environments in arid locations, offices and planes. Controlled wind velocity application of dry air is comparable to low speed fans in patients’ everyday environments, such as in air-conditioned cars.

The Dry Eye Model

• Controls environmental conditions within tight ranges
• Reliably produces participant symptom response
• Reduces variability to enhance efficacy determination
• Exacerbates clinical signs and symptoms, allowing participant recruitment from a wider population
• Provides reproducibility in both subjective and objective measures of dry eye in real-time
• Ensures 100% patient compliance, since subjects are continuously monitored

Experienced staff ocular technicians, optometrists and ophthalmologists working within Cetero’s SOPs have direct “hands on” involvement in every dry eye study we conduct.

We understand that dry eye studies can fail due to inter- and intra-patient variability as dry eye signs and symptoms wax and wane. Cetero’s Dry Eye Model results in studies that have less variability than traditional field trials. They are faster, too. In short, the Cetero approach can give your drug development program better quality data in a shorter time frame, allowing you to make early go/no-go decisions. So don’t wait to find enough patients with reproducible signs and symptoms in a “Dry Eye Hotspot.” Choose a Cetero Dry Eye study instead.